Quantifying the role of angiogenesis in malignant progression of gliomas: In silico modeling integrates imaging and histology Running Title: Malignant Progression and Kinetics of Gliomas

1Department of Pathology, University of Washington School of Medicine, Seattle, WA, USA 98195 2Department of Applied Mathematics, University of Washington, Seattle, WA, USA 98105 3Nancy and Buster Alvord Brain Tumor Center, University of Washington, Seattle, WA, USA 98105 4Division of Mathematics, University of Dundee, Dundee, Scotland, UK DD1 4HN 5Integrated Mathematical Oncology Department, Moffitt Cancer Center and Research Institute, Tampa, FL, USA 33612